Human Lipoprotein (a) is an Antagonist of Fibrinogen that Binds to the GPIIb (CD41) Protein on Agonist-Stimulated Human Platelets
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- BARRE D.E.
- University College of Cape Breton
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Human lipoprotein (a) [Lp(a)] binds to the fibrinogen (GPIIb/IIIa) receptor at the CD41 or GPIIb protein on unstimulated platelets. However, this binding has never been examined on stimulated platelets. Different amounts (1-100 mg%) of purified human Lp(a) and fibrinogen (50 mg/100 ml) were incubated with washed human platelets in the presence or absence of an anti-CD41 monoclonal antibody (Mab) directed at the GPIIb protein of the fibrinogen receptor. Mab inhibited binding of Lp(a) and fibrinogen to the GPIIb protein and abolished Lp(a)-induced reduction of platelet aggregation. In a second experiment, washed platelets were incubated with Lp(a) and Mab or with fibrinogen and Mab and then agonist-stimulated, resulting in a reduction of binding of Lp(a) or fibrinogen. It was concluded that Lp(a) must bind to the GPIIb site to reduce platelet aggregation which apparently occurs via a competition of Lp(a) and fibrinogen for the same site on the IIb portion of the fibrinogen binding site on agonist-stimulated human platelets.<br>
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 53 (6), 305-308, 2004
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679067444224
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- NII論文ID
- 10012946091
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 6943093
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可