魚介類の脂質区に出現する有毒成分の性状と起源

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タイトル別名
  • Chemical Structures, Toxicology, and Biogenetic Origins of Marine Toxins Occurring in Lipid Fractions of Marine Fish and Shellfish.
  • ギョカイルイ ノ シシツク ニ シュツゲンスル ユウドク セイブン ノ セイジ

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説明

Marine toxins occurring in lipid fractions are responsible for three types of seafood poisoning : diarrhetic shellfish poisoning (DSP), neurotoxic shellfish poisoning (NSP), and ciguatera fish poisoning. The major toxins in DSP, okadaic acid and its derivatives, originate from the dinoflagellates Dinophysis spp. The toxins inhibit protein phosphatase 2 A and are potent tumor promotors. Brevetoxins implicated in NSP are produced by the dinoflagellate Gymnodinium breve. The toxins are characterized by contiguous ether rings arranged in a laddershape. Ciguatoxins responsible for ciguatera originating from the dinoflagellate Gambierdiscus toxicus are also bear a ladder-shaped cyclic ether skeleton. Both brevetoxins and ciguatoxins potentiate voltage gated Na channels. All these toxins are highly oxygenated, extremely toxic, and possess high molecular weights. Chemical and biochemical methods for determining the toxins are described.

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  • 日本油化学会誌

    日本油化学会誌 46 (10), 1065-1073, 1997

    公益社団法人 日本油化学会

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