New Method for the Assessment of Biological Effect by Surfactants Using Yeast DNA Microarray

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  • KURITA Sakiko
    National Institute of Advanced Industrial Science and Technology Graduate School of Science and Technology, Chiba University
  • SIRISATTHA Sophon
    National Institute of Advanced Industrial Science and Technology
  • KITAGAWA Emiko
    National Institute of Advanced Industrial Science and Technology
  • MOMOSE Yuko
    National Institute of Advanced Industrial Science and Technology
  • AKAMA Kuniko
    Graduate School of Science and Technology, Chiba University
  • ISHIGAMI Yutaka
    Tokyo Gakugei University
  • IWAHASHI Hitoshi
    National Institute of Advanced Industrial Science and Technology

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  • 酵母ＤＮＡマイクロアレイを用いる，界面活性剤の生体への影響の新しい事前評価法（原標題は英語）

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Spiculisporic acid (a biosurfactant produced by Penicillium spiculisporum) is used in the preparation of detergents, gelation agents, coloring agents for concrete, vesicle forming agents, etc. The effects of biosurfactant and synthetic surfactants (SDS and LAS) were assessed for the first time in this study at the genomic level by yeast DNA microarray bioassay. Hierarchical clustering showed spiculisporic acid to be close to LAS and SDS. The effects of spiculisporic acid on yeast cells would thus appear basically the same as those of LAS and SDS. Gene induction by spiculisporic acid was particularly remarkable in functional categories of “metabolism”, while “cell rescue defense and virulence” and “energy” categories differed from those with SDS and LAS. Thus, spiculisporic acid and SDS might be metabolized via beta-oxidation in two different organelles, mitocondria and peroxisome, respectively. This would explain the low oxidative stress with spiculisporic acid, versus the high oxidative stress with SDS.<br>

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