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- KURITA Sakiko
- National Institute of Advanced Industrial Science and Technology Graduate School of Science and Technology, Chiba University
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- SIRISATTHA Sophon
- National Institute of Advanced Industrial Science and Technology
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- KITAGAWA Emiko
- National Institute of Advanced Industrial Science and Technology
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- MOMOSE Yuko
- National Institute of Advanced Industrial Science and Technology
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- AKAMA Kuniko
- Graduate School of Science and Technology, Chiba University
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- ISHIGAMI Yutaka
- Tokyo Gakugei University
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- IWAHASHI Hitoshi
- National Institute of Advanced Industrial Science and Technology
書誌事項
- タイトル別名
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- New Method for the Assessment of Biological Effect by Surfactants Using Yeast DNA Microarray
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説明
Spiculisporic acid (a biosurfactant produced by Penicillium spiculisporum) is used in the preparation of detergents, gelation agents, coloring agents for concrete, vesicle forming agents, etc. The effects of biosurfactant and synthetic surfactants (SDS and LAS) were assessed for the first time in this study at the genomic level by yeast DNA microarray bioassay. Hierarchical clustering showed spiculisporic acid to be close to LAS and SDS. The effects of spiculisporic acid on yeast cells would thus appear basically the same as those of LAS and SDS. Gene induction by spiculisporic acid was particularly remarkable in functional categories of “metabolism”, while “cell rescue defense and virulence” and “energy” categories differed from those with SDS and LAS. Thus, spiculisporic acid and SDS might be metabolized via beta-oxidation in two different organelles, mitocondria and peroxisome, respectively. This would explain the low oxidative stress with spiculisporic acid, versus the high oxidative stress with SDS.<br>
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 53 (8), 387-398, 2004
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679070222336
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- NII論文ID
- 10013338571
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- NII書誌ID
- AA11503337
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- COI
- 1:CAS:528:DC%2BD2cXmtFSqu7k%3D
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- ISSN
- 13473352
- 13458957
- http://id.crossref.org/issn/13458957
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- NDL書誌ID
- 7005974
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可