NMR study of spontaneous degradation of penicillin G in aqueous solution.
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- Mitsumori Fumiyuki
- Department of Chemistry, Faculty of Science, The University of Tokyo
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- Arata Yoji
- Department of Chemistry, Faculty of Science, The University of Tokyo
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- Fujiwara Shizuo
- Department of Chemistry, Faculty of Science, The University of Tokyo
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- Muranaka Masaharu
- School of Medicine, The University of Tokyo
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- Horiuchi Yoshihiko
- School of Medicine, The University of Tokyo
説明
The spontaneous degradation of penicillin G in aqueous solution has been studied using NMR and thin layer chromatography. Correlation NMR spectroscopy was used to follow products which appear at the early stage of degradation. It has been found that in 0.3 M phosphate buffer (pH 7.0, 30 °C) a successive first order degradation<BR>penicillin G \xrightarrowk1 penicilloic acid \xrightarrowk2 secondary product<BR>is dominant with kinetic constants of k1=0.7×10−2 h−1 and k2=6×10−2 h−1.
収録刊行物
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 50 (12), 3164-3166, 1977
公益社団法人 日本化学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679114633600
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- NII論文ID
- 130001970762
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- ISSN
- 13480634
- 00092673
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
