Microbial conversion of milvemycins: 30-Oxidation of milbemycin A4 and related compounds by Amycolata autotrophica and Amycolatopsis mediterranei.

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  • Microbial conversion of milbemycins: 30-oxidation of milbemycin A4 and related compounds by Amycolata autotrophica and Amycolatopsis mediterranei

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Microorganisms were screened for their ability to modify milbemycin A4 (la). Many strains, mostly actinomycetes and zygomycetes, were found to convert milbemycin A4 (la) to one or more new products. Among these products, M-l, M-2, and M-3 were obtained using Amycolata autotrophica subsp. amethystina ATCC 35204, and were identified as 30-hydroxymilbemycin A4 (1b), 26, 30-dihydroxymilbemycin A4 (Ic), and milbemycin A4 30-oic acid (1d), respectively. Other milbemycins and LL-F28249α (7a) also underwent 30-hydroxylation by the microorganism. 22, 23-Dihydroavermectin B1a (8a) was not hydroxylated at any position by A. autotrophica subsp. amethystina ATCC 35204, but a corresponding hydroxyl product at the C-30 position was obtained using Amycolatopsis mediterranei IFO 13415.

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Details 詳細情報について

  • CRID
    1390282679124337664
  • NII Article ID
    130003501746
  • DOI
    10.7164/antibiotics.43.1321
  • COI
    1:CAS:528:DyaK3MXlvVKgtg%3D%3D
  • ISSN
    18811469
    00218820
  • Text Lang
    en
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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