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Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity.
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- SUGAWARA KOKO
- Bristol-Myers Squibb Research Institute
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- NISHIYAMA YUJI
- Bristol-Myers Squibb Research Institute
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- TODA SOICHIRO
- Bristol-Myers Squibb Research Institute
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- KOMIYAMA NOBUJIRO
- Bristol-Myers Squibb Research Institute
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- HATORI MASAMI
- Bristol-Myers Squibb Research Institute
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- MORIYAMA TOSHIO
- Bristol-Myers Squibb Research Institute
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- SAWADA YOSUKE
- Bristol-Myers Squibb Research Institute
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- KAMEI HIDEO
- Bristol-Myers Squibb Research Institute
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- KONISHI MASATAKA
- Bristol-Myers Squibb Research Institute
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- OKI TOSHIKAZU
- Bristol-Myers Squibb Research Institute
Bibliographic Information
- Other Title
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- PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY
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Description
Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic having a unique unsaturated 12-membered lactone ring.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 45 (9), 1433-1441, 1992
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
