EI-1941-1 and -2, Novel Interleukin-1.BETA. Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941: I. Biochemical Characterization of EI-1941-1 and -2
-
- KOIZUMI FUMITO
- Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
-
- MATSUDA YUZURU
- Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Corporate Planning Department, Kyowa Hakko Kogyo Co., Ltd.
-
- NAKANISHI SATOSHI
- Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Strategic Planning Department, Pharmaceuticals Company, Kyowa Hakko Kogyo Co., Ltd.
書誌事項
- タイトル別名
-
- I. Biochemical Characterization of EI-1941-1 and-2
この論文をさがす
説明
EI-1941-1 and -2 isolated from the culture broths of Farrowia sp. selectively inhibited the human recombinant ICE activity with IC50 values of 0.086 and 0.006μM, respectively, without inhibiting elastase and cathepsin B. EI-1941-1 and -2 also inhibited mature interleukin-1β secretion from THP-1 cells induced by LPS with IC50 values of 5.0 and 10.3μM, respectively. Biochemical characterizations of EI-1941-1 and-2 are described in this article.
収録刊行物
-
- The Journal of Antibiotics
-
The Journal of Antibiotics 56 (5), 464-469, 2003
公益財団法人 日本感染症医薬品協会