Signal Transduction Inhibitors, Hibarimicins A, B, C, D and G Produced by Microbispora. 1. Taxonomy, Fermentation, Isolation and Physico-chemical and Biological Properties.
-
- KAJIURA TAKAYUKI
- Biotechnology Research Center, Toyama Prefectural University
-
- FURUMAI TAMOTSU
- Biotechnology Research Center, Toyama Prefectural University
-
- IGARASHI YASUHIRO
- Biotechnology Research Center, Toyama Prefectural University
-
- HORI HIROSHI
- Faculty of Agriculture, Tamagawa University
-
- HIGASHI KAZUAKI
- Faculty of Agriculture, Tamagawa University
-
- ISHIYAMA TADAYUKI
- Faculty of Agriculture, Tamagawa University
-
- URAMOTO MASAKAZU
- Faculty of Agriculture, Tamagawa University
-
- UEHARA YOSHIMASA
- Department of Bioactive Molecules, National Institute of Infectious Diseases
-
- OKI TOSHIKAZU
- Biotechnology Research Center, Toyama Prefectural University
書誌事項
- タイトル別名
-
- I. Taxonomy, Fermentation, Isolation and Physico-chemical and Biological Properties
この論文をさがす
説明
Strain TP-A0121 which produces a complex of novel tyrosine kinase inhibitors designated hibarimicins A, B, C, D and G was considered to be a new subspecies of Microbispora rosea, and the name, Microbispora rosea subsp. hibaria, was proposed. Hibarimicins A, B, C and D specifically inhibited the src tyrosine kinase activity without affecting protein kinase A or protein kinase C. They also showed in vitro anti-Gram-positive bacterial and antitumor activities. The molecular formulae of hibarimicins A, B, C, D and G were assigned to be C85H112O37, C85H112O37, C83H110O36, C85H112O38, and C85H112O39 respectively.
収録刊行物
-
- The Journal of Antibiotics
-
The Journal of Antibiotics 51 (4), 394-401, 1998
公益財団法人 日本感染症医薬品協会
