Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities.

AMEMIYA MASAHIDE, UENO MITSUHIRO, OSONO MICHIYO, MASUDA TOHRU, KINOSHITA NAOKO, NISHIDA CHIGUSA, HAMADA MAWA, ISHIZUKA MASAAKI, TAKEUCHI OMIO

doi:10.7164/antibiotics.47.536

Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities.

DOI PubMed

AMEMIYA MASAHIDE

Institute for Chemotherapy, M. C. R. F.
UENO MITSUHIRO

Institute for Chemotherapy, M. C. R. F.
OSONO MICHIYO

Institute for Chemotherapy, M. C. R. F.
MASUDA TOHRU

Institute for Chemotherapy, M. C. R. F.
KINOSHITA NAOKO

Institute of Microbial Chemistry, M. C. R. F.
NISHIDA CHIGUSA

Institute of Microbial Chemistry, M. C. R. F.
HAMADA MAWA

Institute of Microbial Chemistry, M. C. R. F.
ISHIZUKA MASAAKI

Institute for Chemotherapy, M. C. R. F.
TAKEUCHI OMIO

Institute for Chemotherapy, M. C. R. F.

書誌事項

タイトル別名

I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES

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説明

Cytostatin has been identified as a novel inhibitor of cell adhesion to components of extracellular matrix (ECM) in cultured broth of Streptomyces sp. MJ654-NF4. Though cytostatin did not inhibit EL-4 cell adhesion to ECM components such as laminin and fibronectin, it inhibited the adhesion of B16 melanoma cells to laminin and collagen type IV but not to fibronectin. It exhibited antimetastatic activity on B16 melanoma cells in mice. The cytotoxicity of cytostatin are also reported.