Antitumor protective property of an isoprenoid antibiotic, ascofuranone.
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- MAGAE JUNJI
- Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
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- HOSOKAWA TOMOYOSHI
- Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
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- ANDO KUNIO
- Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
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- NAGAI KAZUO
- Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
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- TAMURA GAKUZO
- Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
書誌事項
- タイトル別名
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- Antitumor Protective Property of an Iso
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説明
Ascofuranone (AF) showed an antitumor protective effect on L-1210 leukemia when AF was administered once 7 days before tumor challenge. However, effect was not elicited when host mice were treated with AF simultaneously with tumor challenge. AF pretreatment on day 7, 5 and 3 before tumor challenge protected the host from the ascites form of S-180. AF also retarded tumor growth when administered once daily for 5 consecutive days 24 hours after transplantation, but antitumor effect was not seen with combined treatments before and after the transplantation. Similar results were noted with Ehrlich ascites carcinoma. AF treatment of normal mice enlarged the solid lymphoid organs without affecting body weight gain. The splenocytes derived from AF-treated mice lowered mitogenic response to phytohemagglutinin, while the mitogenic response to concanavalin A and lipopolysaccharide was unaffected.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 35 (11), 1547-1552, 1982
公益財団法人 日本感染症医薬品協会
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詳細情報 詳細情報について
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- CRID
- 1390282679127242752
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- NII論文ID
- 130003500169
- 40005315256
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- NII書誌ID
- AA0069330X
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- COI
- 1:CAS:528:DyaL3sXislCmsQ%3D%3D
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- ISSN
- 18811469
- 00218820
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- NDL書誌ID
- 2617089
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- PubMed
- 7161193
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可