Adenophostins A and B: Potent agonists of inositol-1,4,5-trisphosphate receptor produced by Penicillium brevicompactum. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
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- TAKAHASHI MASAAKI
- Fermentation Research Laboratories, Sankyo Co., Ltd.
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- KAGASAKI TAKESHI
- Fermentation Research Laboratories, Sankyo Co., Ltd.
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- HOSOYA TSUYOSHI
- Tsukuba Research Laboratories, Sankyo Co., Ltd.
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- TAKAHASHI SHUJI
- Fermentation Research Laboratories, Sankyo Co., Ltd.
書誌事項
- タイトル別名
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- TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
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説明
New inositol-1, 4, 5-trisphosphate (InsP3) agonists, adenophostins A(1) and B(2), were isolated from the culture broth of Penicillium brevicompactum SANK 11991 and SANK 12177. Its structures were related to adenine nucleotides. The agonistic activity of adenophostins A or B for binding to the InsP3 receptor was higher than InsP3 itself.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 46 (11), 1643-1647, 1993
公益財団法人 日本感染症医薬品協会
