Bequinostatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.

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  • PRODUCTION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL ACTIVITIES

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New benzo[a]naphthacenequinone metabolites, designated bequinostatins A and B, have been isolated from the culture broth of the benastatin-producing strain Streptomyces sp. MI384-DF12. The structures of bequinostatins A and B were determined by spectral analyses to be 5, 6, 8, 13-tetrahydro-1, 6, 7, 9, 11-pentahydroxy-8, 13-dioxo-3-pentylbenzo[a]naphthacene-2-carboxylic acid and 2-decarboxybequinostatin A, respectively. Bequinostatin A showed considerable inhibitory activity against human pi class glutathione S-transferase (GST π).

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Details 詳細情報について

  • CRID
    1390282679127975680
  • NII Article ID
    130003502563
  • DOI
    10.7164/antibiotics.46.914
  • COI
    1:CAS:528:DyaK2cXhtVWgsL8%3D
  • ISSN
    18811469
    00218820
  • PubMed
    8344872
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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