Erabulenols, Inhibitors of Cholesteryl Ester Transfer Protein Produced by Penicillium sp. FO-5637. II. Structure Elucidation of Erabulenols A and B.

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  • TABATA NORIKO
    Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University
  • TOMODA HIROSHI
    Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University
  • OMURA SATOSHI
    Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University

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Other Title
  • II. Structure Elucidation of Erabulenols A and B

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Description

Structures of erabulenols A and B, novel fungal inhibitors of cholesteryl ester transfer protein were elucidated by spectroscopic studies including various NMR measurements. Erabulenols consist of a phenalenone skeleton and a 1, 2, 2-trimethyltetrahydrofuran moiety in common. Erabulenol B possesses an additional 2, 6-dihydroxy-5-methyl-3-methylketonyl benzyl moiety. The absolute stereochemistry at the C-2′ position of erabulenol A was deduced as S by comparison of the optical rotation with that of other related compounds.

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Details 詳細情報について

  • CRID
    1390282679128304640
  • NII Article ID
    130003503473
  • DOI
    10.7164/antibiotics.51.624
  • COI
    1:CAS:528:DyaK1cXltVyhtbo%3D
  • ISSN
    18811469
    00218820
  • PubMed
    9727387
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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