The pivotal position of the mitochondrial thiol group exposed by dinitrophenol located by means of ATP energized mitochondrial volume changes requiring gramicidin,showdomycin,and dinitrophenol
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- HADLER HERBERT I.
- Department of Chemistry, Southern Illinois University
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- CLAYBOURN BOB E.
- Department of Chemistry, Southern Illinois University
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- TSCHANG TAI Po
- Department of Chemistry, Southern Illinois University
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- MOREAU TERRY L.
- Department of Chemistry, Southern Illinois University
書誌事項
- タイトル別名
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- THE PIVOTAL POSITION OF THE MITOCHONDRIAL THIOL GROUP EXPOSED BY DINITROPHENOL LOCATED BY MEANS OF ATP ENERGIZED MITOCHONDRIAL VOLUME CHANGES REQUIRING GRAMICIDIN, SHOWDOMYCIN, AND DINITRIPHENOL
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説明
An appropriate concentration of DNP (2, 4-dinitrophenol) is capable of inhibiting the ATP energized mitochondrial volume change induced by gramicidin in the presence of the permeant ions potassium and L-malate. The further addition of the non-mercurial thiol reagent, showdomycin reinstates, an effect of gramicidin which is dependent upon potassium ion. Thus the strategically located nucleophilic mitochondrial thiol group exposed by DNP occupies a pivotal position between two cycles. One of the cycles meshes with the respiratory chain and the other cycle meshes with ATP. This latter cycle contains the site sensitive to gramicidin.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 22 (5), 183-188, 1969
公益財団法人 日本感染症医薬品協会
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詳細情報 詳細情報について
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- CRID
- 1390282679129375488
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- NII論文ID
- 130003498180
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- NII書誌ID
- AA0069330X
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- COI
- 1:CAS:528:DyaF1MXkt1Sltbs%3D
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- ISSN
- 18811469
- 00218820
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- NDL書誌ID
- 8510043
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- PubMed
- 5811390
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可