The pivotal position of the mitochondrial thiol group exposed by dinitrophenol located by means of ATP energized mitochondrial volume changes requiring gramicidin,showdomycin,and dinitrophenol

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  • THE PIVOTAL POSITION OF THE MITOCHONDRIAL THIOL GROUP EXPOSED BY DINITROPHENOL LOCATED BY MEANS OF ATP ENERGIZED MITOCHONDRIAL VOLUME CHANGES REQUIRING GRAMICIDIN, SHOWDOMYCIN, AND DINITRIPHENOL

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An appropriate concentration of DNP (2, 4-dinitrophenol) is capable of inhibiting the ATP energized mitochondrial volume change induced by gramicidin in the presence of the permeant ions potassium and L-malate. The further addition of the non-mercurial thiol reagent, showdomycin reinstates, an effect of gramicidin which is dependent upon potassium ion. Thus the strategically located nucleophilic mitochondrial thiol group exposed by DNP occupies a pivotal position between two cycles. One of the cycles meshes with the respiratory chain and the other cycle meshes with ATP. This latter cycle contains the site sensitive to gramicidin.

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