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- MIZUNO KIMIO
- Research Laboratories, Toyo Jozo Co., Ltd.
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- TSUJINO MASATOSHI
- Research Laboratories, Toyo Jozo Co., Ltd.
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- TAKADA MASAKI
- Research Laboratories, Toyo Jozo Co., Ltd.
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- HAYASHI MITSUO
- Research Laboratories, Toyo Jozo Co., Ltd.
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- ATSUMI KIYOO
- Research Laboratories, Toyo Jozo Co., Ltd.
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- ASANO KATSUMI
- Research Laboratories, Toyo Jozo Co., Ltd.
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- MATSUDA TETSUO
- Research Laboratories, Toyo Jozo Co., Ltd.
書誌事項
- タイトル別名
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- Studies on bredinin. I. Isolation, characterization and biological properties.
- ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES
説明
Bredinin, C9H13N3O6, is, a novel imidazole nucleoside with an immunosbppressive activity. It was isolated from the culture filtrate of Eupenicillium brefeldianum M-2166 by means of ion-exchange or partition chromatography. Bredinin shows selective cytotoxicity against L5178Y cells derived from malignant lymphoma of the mouse. As an immunosuppressant, it has favorable characteristics, namely, a potent activity, low acute toxicity, and a slight effect on a decrease of peripheral leukocytes. Bredinin inhibits the growth of vaccinia virus but not that of bacteria or fungi except for Candida albicans in vitro.<br>Slight prolongation in the survival period of mice inoculated with lymphatic leukemia L1210 was observed by intraperitoneal injection of bredinin, however, it was not effective on P388 leukemia or EHRLICH ascites tumor.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 27 (10), 775-782, 1974
公益財団法人 日本感染症医薬品協会