.BETA.-Lactam antibiotics. I. Comparative structure-activity relationships of 6-acylaminopenicillanic acid derivatives and their 6-(D-.ALPHA.-acylaminophenylacetamido) penicillanic acid analogues.

DOI PubMed 1 Citations

Bibliographic Information

Other Title
  • COMPARATIVE STRUCTURE-ACTIVITY RELATIONSHIPS OF 6-ACYLAMINOPENICILLANIC ACID DERIVATIVES AND THEIR 6-(D-α-ACYLAMINOPHENYLACETAMIDO) PENICILLANIC ACID ANALOGUES

Search this article

Description

Structure-activity relationships were compared for two series of penicillins containing a common acyl group. In series I, which included most of the penicillins in clinical use, the acyl moiety was linked directly to the amino group of the penicillin nucleus. For series II the acyl moiety was linked to the amino group of D-α-aminobenzylpenicillin (ampicillin). In the majority of cases a striking similarity between the two series was observed. The correlation provided both a valuable means of classifying and predicting the antibacterial properties of one series from a knowledge of the other.

Journal

Citations (1)*help

See more

Keywords

Details 詳細情報について

  • CRID
    1390282679130312576
  • NII Article ID
    130003498800
  • DOI
    10.7164/antibiotics.27.922
  • COI
    1:CAS:528:DyaE2MXhtlent7Y%3D
  • ISSN
    18811469
    00218820
  • PubMed
    4219783
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • Abstract License Flag
    Disallowed

Report a problem

Back to top