FR227244, a Novel Antifungal Antibiotic from Myrothecium cinctum No.002: I.Taxonomy, Fermentation, Isolation and Physico-chemical Properties

DOI
  • KOBAYASHI MOTOO
    Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • KANASAKI RYUICHI
    Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • EZAKI MASAMI
    Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • SAKAMOTO KAZUTOSHI
    Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • TAKASE SHIGEHIRO
    Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • FUJIE AKIHIKO
    Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • HINO MOTOHIRO
    Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
  • HORI YASUHIRO
    Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd. PMD Research Center, Fujisawa Pharmaceutical Co., Ltd.

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Other Title
  • I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties

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Description

A novel antifungal antibiotic, FR227244, was isolated from the culture broth of a fungal strain No. 002. The strain was identified as Myrothecium cinctum from morphological and physiological characteristics. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatographies, and n-hexane precipitation. FR227244 is a white powder which melts at 210-211°C and possesses the molecular formula C38H58O11.<br>FR227244 is a novel triterpene glycoside with antifungal activity against Aspergillus fumigatus. The effects of FR227244 on the morphology of A. fumigatus were shown to be similar to those of FR901379 which is a known 1, 3-β-glucan synthase inhibitor.

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Details 詳細情報について

  • CRID
    1390282679131552384
  • NII Article ID
    130003504134
  • DOI
    10.7164/antibiotics.57.780
  • COI
    1:CAS:528:DC%2BD2MXhvFaqsQ%3D%3D
  • ISSN
    18811469
    00218820
  • Text Lang
    en
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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