Structure-activity relationships among negamycin analogs.

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  • Structure activity relationships among

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Various negamycin analogs were examined for (1) miscoding activity and (2) inhibition of the termination of protein synthesis. Since properties (1) and (2) do not correlate for the investigated compounds they may depend on different structural features of negamycin analogs. The results of biochemical and antimicrobial studies indicate that (a) the natural configuration of the carbon atom carrying the β-amino group is essential, (b) the δ-hydroxyl group is unnecessary, and (c) the acylation of the ε-amino group causes loss of activity.

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