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- UEHARA YOSHIMASA
- Institute of Microbial Chemistry
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- HORI MAKOTO
- Institute of Microbial Chemistry
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- KONDO SHINICHI
- Institute of Microbial Chemistry
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- HAMADA MASA
- Institute of Microbial Chemistry
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- UMEZAWA HAMAO
- Institute of Microbial Chemistry
書誌事項
- タイトル別名
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- Structure activity relationships among
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説明
Various negamycin analogs were examined for (1) miscoding activity and (2) inhibition of the termination of protein synthesis. Since properties (1) and (2) do not correlate for the investigated compounds they may depend on different structural features of negamycin analogs. The results of biochemical and antimicrobial studies indicate that (a) the natural configuration of the carbon atom carrying the β-amino group is essential, (b) the δ-hydroxyl group is unnecessary, and (c) the acylation of the ε-amino group causes loss of activity.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 29 (9), 937-943, 1976
公益財団法人 日本感染症医薬品協会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679131646208
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- NII論文ID
- 130003499257
- 40005313894
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- NII書誌ID
- AA0069330X
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- COI
- 1:CAS:528:DyaE28XlslahsLo%3D
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- ISSN
- 18811469
- 00218820
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- NDL書誌ID
- 1726702
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- PubMed
- 791912
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可