書誌事項
- タイトル別名
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- Autoradiography of Lyophilized Animal Sections: Bone Density Measurement in Osteoporosis Model Rats
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抄録
To gain a better understanding on the β-ray radiography of lyophilized animal sections, the bone densities of the osteoporosis rats were measured using a 147Pm planar radiation source. An imaging plate as a radiation sensor was overlaid on the animal section together with a density calibrator. After exposure, radioactivity recorded on the sensor was quantified using a bio-imaging analyzer. The density calibration curve showed linearity in the wide range with a good correlation coefficient(R2≥0.999). The inter- and intra-plate variability showed CV values less than 3.7%. On the measurement of bone density, bone density differences between the sham group and ovariectomized(OVX)group were statistically significant in the femoral cortical(p=0.001)and trabecular bone(p=0.07), and vertebral trabecular bone(p=0.043). Based on these results, we developed a new and valuable method, which made it possible to measure bone density of axial skeleton of a rat, as an alternative to commonly used methods.
収録刊行物
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- RADIOISOTOPES
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RADIOISOTOPES 57 (2), 111-119, 2008
公益社団法人 日本アイソトープ協会
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詳細情報 詳細情報について
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- CRID
- 1390282679132273024
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- NII論文ID
- 130004511478
- 10021071329
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- NII書誌ID
- AN00351589
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- ISSN
- 18844111
- 00338303
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- NDL書誌ID
- 9386074
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可