A Comparative Study of the Biological Effects of Neutron Beams with Different Energy Profiles

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  • 異なるエネルギープロファイルをもつ中性子ビームの生物影響の比較

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An important application of neutron beam is boron neutron capture therapy(BNCT). Many facilities have recently been planning to use an accelerator for BNCT, in which cancer cells as well as normal cells near a cancerous region may be exposed to neutron beams with different energy profiles. In the present study, the cell killing effect and induction of DNA double-strand breaks(DNA-dsb) by neutron beams of different energy profiles were studied in Chinese hamster ovary(CHO-K1) cells and their radiosensitive mutant(xrs-5) cells. A neutron beam with mean energy 2MeV generated by the Neutron Exposure Accelerator System for Biological Effect Experiments(NASBEE) was more effective for cell killing than the thermal to epithermal neutron beams generated by the Heavy Water Facility of the Kyoto University Research Reactor(KUR-HWF). A focus assay of the repair protein of 53BP1 revealed a significant induction of DNA-dsb by these two neutron beams, but no significant difference in the induction and repair capabilities was noted between the two. These data suggest that an increase in the mean energy of neutron beam from thermal to fast neutrons increases cell killing effects, but not the induction of DNA-dsb.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 64 (5), 291-297, 2015

    Japan Radioisotope Association

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