周期律第VII族元素のがんおよび臓器親和性

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  • Affinity for a Malignant Tumor and Organs at the Elements in Group VII of the Periodic Table

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In order to investigate the tumor affinity radioisotopes, manganese (54Mn), technetium (99mTc), rhenium (186Re), bromine (82Br) and iodine (131I) -the elements of group VII in the periodic table-were examined, using the rats which were subcutaneously transplanted with Yoshida sarcoma. Five preparations, manganese chloride (54MnCl2), sodium pertechnetate (Na99mTcO4), sodium perrhenate (Na186ReO4), ammonium bromide (NH482Br) and sodium iodide (Na131I) were injected intravenously to each group of tumor bearing rats. These rats were sacrificed at various periods after injection of each preparation: 3 hours, 24 hours and 48 hours in all preparations but sodium pertechnetate, 1 hour, 3 hours and 24 hours in sodium pertechnetate. The radioactivities of the tumor, blood, muscle, liver, kidney spleen and others were measured by a well-type scintillation counter, and retention values (in every tissue including the tumor) were calculated in percent of administered dose per g-tissue weight.<BR>All of five preparations did not have any affinity for malignant tumor. 54MnCl2 was excreted very slowly out of the body and had some affinity for the pancreas. As Na99mTcO4 and Na186ReO4 was rapidly excreted into the urine, retention values of these two compounds in the organs was very small. NH482Br was excreted very slowly out of the body. In Na131I, a large amount of iodine-131I was accumulated into the thyroid, but retention values of Na131I in other organs was very small.

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