A Reductive Acidolysis Final Deprotection Strategy in Solid Phase Peptide Synthesis Based on Safety-Catch Protection.

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  • Reductive Acidolysis Final Deprotection

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A reductive acidolysis final deprotection strategy in solid phase peptide synthesis was developed using a new safety-catch type of semi-permanent protecting groups and new linkers which were derived from 4-methylsulfinylbenzyl protection. This new strategy was based on a two-dimensional protection scheme employing acid-labile temporary and acid-stable but reductive acidolysis-cleavable semi-permanent protecting groups. By using this strategy, we successfully synthesized four model peptides, of which two contained C-terminal amide.

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