A Facile Method for the Stereoselective Horner-Wadsworth-Emmons Reaction of Aryl Alkyl Ketones.

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  • Facile Method for the Stereoselective Horner Wadsworth Emmons Reaction of Aryl Alkyl Ketones

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Excellent Z or E selectivity was observed in the Horner–Wadsworth–Emmons (HWE) reactions of methyl bis(2,2,2-trifluoroethyl)phosphonoacetate or ethyl 2-fluoro-2-diethylphosphonoacetate with aryl alkyl ketones bearing substituents on an aromatic moiety employing Sn(OSO2CF3)2 in the presence of N-ethylpiperidine.

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