trans-4-Methylcyclohexylamine, a potent new inhibitor of spermidine synthase.
書誌事項
- 公開日
- 1988
- 資源種別
- journal article
- DOI
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- 10.1248/cpb.36.3220
- 公開者
- 公益社団法人 日本薬学会
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説明
Trans-4-methylcyclohexylamine was found to inhibit pig spermidine synthase potently in assay conditions containing 50 μM of decarboxylated S-adenosylmethionine. It showed 50% inhibition at 1.7 μM compared to 8.1 μM for cyclohexylamine, and 2.5 μM for S-adenosyl-1, 8-diamino-3-thiooctane, known as the most potent inhibitor. The inhibition was competitive with putrescine, similar to cyclohexylamine, and the Ki was 40 nM.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 36 (8), 3220-3222, 1988
公益社団法人 日本薬学会
