Constituents of Hypericum laricifolium and Their Cyclooxygenase (COX) Enzyme Activities

El-Seedi Hesham Rushdey, Ringbom Therese, Torssell Kurt, Bohlin Lars

doi:10.1248/cpb.51.1439

Constituents of Hypericum laricifolium and Their Cyclooxygenase (COX) Enzyme Activities

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El-Seedi Hesham Rushdey

Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University
Ringbom Therese

Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University
Torssell Kurt

Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University
Bohlin Lars

Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University

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説明

Investigation of the aerial parts of the medicinal plant Hypericum laricifolium led to the isolation of two new natural products, hentriacontanyl caffeate (1a), nonacosanyl caffeate (1b). In addition, stigmasterol, β-sitosterol, 3-epi-betulinic acid (2), caffeic acid (3), ferulic acid, docosanol, p-hydroxybenzoic acid, 3,4-dimethoxy benzoic acid, quercetin (4), quercetin-3-O-galactoside (5), quercetin-3-O-rutinoside (6), quercetin-3-O-rhamnoside (7), quercetin-3-O-glucuronide (8) and shikimic acid were also isolated. The structures were determined by 1D- and 2D-NMR, mass spectrometry, and chemical transformations. The anti-inflammatory effects of the isolated compounds were discussed briefly.