Thalidomide Analogs from Diamines: Synthesis and Evaluation as Inhibitors of TNF-α Production

Almeida Mauro Vieira de, Teixeira Francisco Martins, Souza Marcus Vinicius Nora de, Amarante Giovanni Wilson, Alves Caio César de Souza, Cardoso Sílvia Helena, Mattos Ana Márcia, Ferreira Ana Paula, Teixeira Henrique Couto

doi:10.1248/cpb.55.223

Thalidomide Analogs from Diamines: Synthesis and Evaluation as Inhibitors of TNF-α Production

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Almeida Mauro Vieira de

Department of Chemistry, ICE, Federal University of Juiz de Fora
Teixeira Francisco Martins

Laboratory of Immunology, Department of Parasitology, Microbiology and Immunology, ICB, Federal University of Juiz de Fora
Souza Marcus Vinicius Nora de

Department of Chemistry, ICE, Federal University of Juiz de Fora
Amarante Giovanni Wilson

Department of Chemistry, ICE, Federal University of Juiz de Fora
Alves Caio César de Souza

Laboratory of Immunology, Department of Parasitology, Microbiology and Immunology, ICB, Federal University of Juiz de Fora
Cardoso Sílvia Helena

Department of Chemistry, ICE, Federal University of Juiz de Fora
Mattos Ana Márcia

Laboratory of Immunology, Department of Parasitology, Microbiology and Immunology, ICB, Federal University of Juiz de Fora
Ferreira Ana Paula

Laboratory of Immunology, Department of Parasitology, Microbiology and Immunology, ICB, Federal University of Juiz de Fora
Teixeira Henrique Couto

Laboratory of Immunology, Department of Parasitology, Microbiology and Immunology, ICB, Federal University of Juiz de Fora

書誌事項

タイトル別名

Thalidomide Analogs from Diamines: Synthesis and Evaluation as Inhibitors of TNF-.ALPHA. Production
Thalidomide Analogs from Diamines Synthesis and Evaluation as Inhibitors of TNF アルファ Production

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説明

Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83—94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An in vitro investigation of the compounds as inhibitors of the TNF-α production was performed. The inhibition was higher for compounds bearing amino and nitro groups and was modulated by increasing the size of the spacers between the phthalimide groups.