Molecular Weight Determination of Hypromellose Acetate Succinate (HPMCAS) Using Size Exclusion Chromatography with a Multi-Angle Laser Light Scattering Detector

DOI Web Site Web Site PubMed 4 References
  • Fukasawa Miyuki
    Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd.
  • Obara Sakaé
    Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd.

Bibliographic Information

Other Title
  • Molecular Weight Determination of Hypromellose Acetate Succinate (HPMCAS) Using Size Chromatography with a Muiti-Angle Laser Light Scattering Detector

Search this article

Description

The molecular weight of hypromellose acetate succinate (HPMCAS), a polymer used for enteric coating, was determined by means of size exclusion chromatography with a multi-angle laser light scattering detector. The weight-average molecular weight (Mw) of several lots and grades ranged approximately from 17000 to 20000, and the number-average molecular weight (Mn) was around 13000. The inter-day precision of measurement, in terms of the coefficient of variation, was less than 5%.

Journal

References(4)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top