Synthesis and optical resolution of 2-aryl-2-fluoropropionic acids, fluorinated analogues of non-steroidal anti-inflammatory drugs

DOI DOI Web Site Web Site PubMed 被引用文献3件 参考文献30件 オープンアクセス
  • Fujisawa Hidehito
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • Fujiwara Tomoya
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • Takeuchi Yoshio
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • Omata Kenji
    Department of Chemistry, Graduate School of Science, Tohoku University

書誌事項

タイトル別名
  • Synthesis and Optical Resolution of 2-Aryl-2-fluoropropionic Acids, Fluorinated Analogues of Non-steroidal Anti-inflammatory Drugs (NSAIDs)
公開日
2005
資源種別
journal article
DOI
  • 10.1248/cpb.53.524
  • 10.1002/chin.200546075
公開者
公益社団法人 日本薬学会

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説明

We report the synthesis of optically active 2-aryl-2-fluoropropionic acids 2 as non-epimerizable mimics of 2-arylpropionic acids 1, a class of compounds which have been widely used as non-steroidal anti-inflammatory drugs (NSAIDs). This is a continuation of our research involving the design, synthesis, and evaluation of chiral fluorine-containing organic molecules as effective analogues of pharmacologically important compounds.

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