Concise Synthesis of Dimemorfan (DF) Starting from 3-Hydroxymorphinan (3-HM)

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  • Kim Jong Yup
    Small Molecule Group, Central Research Institute, Green Cross Corporation
  • Kim Hyoung-Chun
    College of Pharmacy, Kangwon National University
  • Kim Jeongmin
    Small Molecule Group, Central Research Institute, Green Cross Corporation
  • Lee Jinhwa
    Small Molecule Group, Central Research Institute, Green Cross Corporation

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説明

Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available 3-hydroxymorphinan (3-HM) is disclosed. Other morphinan analogs have been effectively prepared by adopting the similar methodology.

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