Synthesis of Spiro [4-hydroxycyclohexane-1, 4'-2', 3'-dihydro-6'-methoxy-2'-methyl-1'H-isoquinoline]

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For the purpose of testing the biological activity, spiro [4-hydroxycyclohexane-1, 4'-2', 3'-dihydro-6'-methoxy-2'-methyl-1'H-isoquinoline] (III) was synthesized by a sequence of reactions including the Schmidt reaction on the indanone (XIV). The compound (III) was found to have a considerably lower anti-cholinesterase activity than galanthamine (I).

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