Two New Drimane Sesquiterpenoids from Compound Changweikang and Their Inhibitory Activity against Nitric Oxide Production

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  • Liu Ming-sheng
    School of Pharmaceutical Sciences, Hainan Medical University Hainan Provincial Key Laboratory of R&D of Tropical Herbs
  • Liu Chang
    School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
  • Zhang Xiao-po
    School of Pharmaceutical Sciences, Hainan Medical University
  • Sheng Lin
    School of Pharmaceutical Sciences, Hainan Medical University Hainan Provincial Key Laboratory of R&D of Tropical Herbs
  • Zhang Jun-qing
    School of Pharmaceutical Sciences, Hainan Medical University Hainan Provincial Key Laboratory of R&D of Tropical Herbs
  • Kang Sheng-li
    School of Pharmaceutical Sciences, Hainan Medical University Hainan Provincial Key Laboratory of R&D of Tropical Herbs

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Two new drimane sesquiterpenoids, changweikangic acid A (1) and B (2), were isolated from Compound Changweikang. Their structures were established on basis of extensive spectroscopic analyses including two dimensional (2D) NMR and X-ray crystallographic data. The two compounds were evaluated for their inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophage cell line, RAW 264.7 cells.

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