Flavonoids from Daphne aurantiaca and Their Inhibitory Activities against Nitric Oxide Production

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  • Liang Shuang
    School of Pharmacy, Shanghai Jiaotong University Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, People's Republic of China
  • Tian Jun-Mian
    Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, People's Republic of China
  • Feng Yi
    Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, People's Republic of China
  • Liu Xiao-Hua
    Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, People's Republic of China
  • Xiong Zhi
    Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, People's Republic of China
  • Zhang Wei-Dong
    School of Pharmacy, Shanghai Jiaotong University Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, People's Republic of China

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Chemical examination of the methanolic extract from the stem bark of Daphne aurantiaca led to the isolation of three new flavonoids (1—3), and 29 known flavonoids. All 32 compounds were isolated for the first time from Daphne aurantiaca. The isolates were tested for inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages. Compounds 21 and 24 showed potent inhibitory activities against the production of NO with IC50 values of 0.006 and 0.076 μM, respectively.

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