An Artificial Copper Complex Incorporating a Cell-Penetrating Peptide Inhibits Nuclear Factor-κB (NF-κB) Activation
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- Kanemaru Yosuke
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
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- Momiki Yumi
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
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- Matsuura Saori
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
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- Horikawa Tatsufumi
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
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- Gohda Jin
- Research Institute for Drug Discovery, School of Pharmacy, Kumamoto University
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- Inoue Jun-ichiro
- Research Institute for Drug Discovery, School of Pharmacy, Kumamoto University
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- Okamoto Yoshinari
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
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- Fujita Mikako
- Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo
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- Otsuka Masami
- Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University
書誌事項
- タイトル別名
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- An Artificial Copper Complex Incorporating a Cell-Penetrating Peptide Inhibits Nuclear Factor-.KAPPA.B (NF-.KAPPA.B) Activation
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説明
Nuclear factor-κB (NF-κB) is an inducible transcription factor activated by a variety of cytokines, and promotes the transcription of genes involved in cancer, inflammation, autoimmune disease, and viral infection, among others. Because of its involvement in numerous disease processes, considerable research has focused on NF-κB as a potential drug target. We previously reported that cupric ion (Cu2+) blocks NF-κB activation. However, Cu2+ is unsuitable for drug applications. The copper complex of an artificial peptide HPH-Pep (HPH-Pep-Cu2+) was a promising alternative, but it did not easily cross the cell membrane. We report the development of a NF-κB inhibiting Cu2+ complex with improved cell-penetrating activity arising from the coupling of a Tat peptide to HPH-Pep-Cu2+.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 59 (12), 1555-1558, 2011
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679150904064
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- NII論文ID
- 130001852132
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 023321247
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可