Highlighted Paper selected by Editor-in-Chief : Four New Lignans and IL-2 Inhibitors from Magnoliae Flos

DOI Web Site Web Site PubMed 被引用文献2件 参考文献31件
  • Nguyen Thi Tuyet Mai
    College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University
  • Lee Hyun-Su
    College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu School of Life Sciences, Immune Synapse Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology
  • Nguyen Thi Thu
    College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University
  • Ngo Thi Quynh Mai
    College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu
  • Jun Chang-Duk
    School of Life Sciences, Immune Synapse Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology
  • Min Byung Sun
    College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu
  • Kim Jeong Ah
    College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University

書誌事項

タイトル別名
  • Four New Lignans and IL-2 Inhibitors from Magnoliae Flos

この論文をさがす

説明

<p>Four new lignans, a furofuran lignan medioresinol B (10) and three tetrahydrofuran lignans kobusinol C (16), 7′-methoxy magnostellin A (21), and mangnostellin D (23), along with 19 known lignans, were isolated from the flower buds of Magnolia biondii PAMP. The structures of the isolates were elucidated using spectroscopic analysis, mainly one- and two-dimensional NMR, high resolution-MS, and circular dichroism techniques as well as Mosher’s esterification method. The anti-allergic effects of the isolated compounds were evaluated by analyzing the inhibition of interleukin-2 (IL-2) expression in Jurkat T-cells. Compounds 11–14 reduced IL-2 expression in a dose-dependent manner.</p>

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (31)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ