A Novel Clerodane Diterpene from <i>Vitex cofassus</i>
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- Rasyid Faradiba Abdul
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Fukuyoshi Shuichi
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Ando Hirokazu
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Miyake Katsunori
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Atsumi Toshiyuki
- School of Pharmacy, Kyushu University of Health and Welfare
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- Fujie Tetsuo
- Advanced Science Research Center, Kanazawa University
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- Saito Yohei
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Goto Masuo
- UNC Eshelman School of Pharmacy, University of North Carolina
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- Shinya Tomohiro
- School of Pharmacy, Kyushu University of Health and Welfare
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- Mikage Masayuki
- Faculty of Agriculture, Tokyo University of Agriculture
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- Sasaki Yohei
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Nakagawa-Goto Kyoko
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University UNC Eshelman School of Pharmacy, University of North Carolina
Bibliographic Information
- Other Title
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- A Novel Clerodane Diterpene from Vitex cofassus
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Description
<p>New clerodane diterpene, 16-hydroxy-pentandralactone (1) and known diterpene acuminolide (2) were isolated from the methanol extract of Vitex cofassus leaves. The chemical structure and the absolute configuration of 1 were determined by MS, NMR and electron circular dichroism (ECD) experiments. The isolated compounds were evaluated for their antiproliferative activities against a panel of human tumor cell lines, including a multidrug-resistant (MDR) cell line. Both compounds showed potent antiproliferative activities against all the tested cell lines with IC50 values of 5.4–11.4 µM. Their effects on cell viability were also tested using vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cells (HUVECs). Compound 1 inhibited VEGF-stimulated HUVEC proliferation in a dose-dependent manner. Based on these results, compound 1 could be a candidate for antitumor agent and inhibitor of angiogenesis.</p>
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 65 (1), 116-120, 2017
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679154530304
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- NII Article ID
- 130005187753
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 027820084
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- PubMed
- 28049908
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed