Total Synthesis of Biologically Active Natural Products Based on Highly Selective Synthetic Methodologies

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  • Hatakeyama Susumi
    Graduate School of Biomedical Sciences, Nagasaki University, 1–14 Bunkyo-machi, Nagasaki 852–8521, Japan

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Abstract

Total syntheses of structurally and biologically intriguing natural products relying on new synthetic methodologies are described. This article features cinchona alkaloid-catalyzed asymmetric Morita–Baylis–Hillman reactions, heterocycle syntheses based on rhodium-catalyzed C–H amination and indium-catalyzed Conia-ene reactions, and their utilization for the syntheses of the phoslactomycin family of antibiotics, glutamate receptor agonists and antagonists, and alkaloids with characteristic highly substituted pyrrolidinone core structures.

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