書誌事項
- タイトル別名
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- Inhibition of alanine aminotransferase activity by IgG.
- ALT カッセイ ソガイ オ シメス IgG ノ メンエキ カガクテキ トクセイ
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抄録
We observed a 74-year old woman with chronic hepatitis C, whose alanine aminotransferase (L-Alanine: 2-oxoglutarate aminotransferase: EC.2.6. 1.2; ALT) activity in serum was below 2 IU/L (reference value: 9-25 IU/L). ALT activity in normal human serum was inhibited when the patient's serum was added to normal serum. By immunoprecipitation assay, it was found that the patient's IgG-κ acted as an inhibitor of ALT. The ALT inhibition of the patient's IgG was not blocked by adding alanine as a substrate, and also by adding pyridoxal phosphate as a coenzyme. The purified patient's IgG was found to be composed of two γ chains of about 50kDa and two κ chains of 28kDa by SDS-PAGE. The inhibitory ability of IgG was exclusively located in the Fab region of the molecule.
収録刊行物
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- 生物物理化学
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生物物理化学 50 (4), 225-229, 2006
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詳細情報 詳細情報について
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- CRID
- 1390282679177498880
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- NII論文ID
- 10018441597
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- NII書誌ID
- AN00129729
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- ISSN
- 13499785
- 00319082
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- NDL書誌ID
- 8615624
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可