A Tear Production Assessment by Using Schirmer Tear Test Strips in Mice, Rats and Dogs

DOI
  • SHIRAKI Takeshi
    Takeda Pharmaceutical Company Limited, Development Research Center, Hikari Branch
  • SHIGETA Masaki
    Takeda Pharmaceutical Company Limited, Development Research Center, Hikari Branch
  • TAHARA Noriko
    Takeda Pharmaceutical Company Limited, Development Research Center, Hikari Branch
  • FURUKAWA Hatsue
    Takeda Pharmaceutical Company Limited, Development Research Center, Hikari Branch
  • OHTSUKA Hirohiko
    Takeda Pharmaceutical Company Limited, Development Research Center, Hikari Branch

Bibliographic Information

Other Title
  • シルマー試験紙を利用したマウス、ラットおよびイヌにおける涙液分泌量評価

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Description

Effects of atropine and pilocarpine on a tear production were assessed in mice, rats and dogs by using commercialized Schirmer tear test strips. The test strips were cut into strips of 1.5 mm width for mice, 3.0 mm width for rats and 5.0 mm width for dogs. Atropine was injected subcutaneously at 1 mg/kg for mice, rats and dogs, and pilocarpine was injected subcutaneously at 30 mg/kg for mice and rats or at 3 mg/kg for dogs. In all species, this Schirmer tear test was detected a decrease in tear production after the treatment of atropine and an increase after the treatment of pilocarpine. These results suggest that measurement of the tear production can be performed in various species by a use of variable width of the commercialized Schirmer tear test strips, and this modified method is useful for assessment of visual toxicity.

Journal

  • Animal Eye Research

    Animal Eye Research 24 (1-2), 1-2_1-1-2_5, 2005

    Japanese Society of Comparative and Veterinary Ophthalmology

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