Anti-fungal Drug Liranaftate Suppresses Fungal Element-promoted Production of IL-8 in Normal Human Keratinocytes

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  • Kobayashi Miwa
    Department of Dermatology, University of Occupational and Environmental Health
  • Kabashima Kenji
    Department of Dermatology, University of Occupational and Environmental Health
  • Tokura Yoshiki
    Department of Dermatology, University of Occupational and Environmental Health

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Other Title
  • 表皮ケラチノサイトのＩＬ‐８産生に対する真菌成分の影響と，抗真菌薬リラナフタートによる抑制効果
  • 表皮ケラチノサイトのIL-8産生に対する真菌成分の影響と,抗真菌薬リラナフタートによる抑制効果
  • ヒョウヒ ケラチノサイト ノ IL-8 サンセイ ニ タイスル シンキン セイブン ノ エイキョウ ト,コウシンキンヤク リラナフタート ニ ヨル ヨクセイ コウカ

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Dermatophytes reside in the stratum corneum of the epidermis, and one scenario in superficial dermatophytosis is that fungi stimulate keratinocytes to secrete chemokines, thereby attracting inflammatory cells. We investigated the effect of the cytokine ⁄ chemokine production of keratinocytes solely stimulated by fungal elements. The fungal elements β -D-glucan and trichophytin from Trichophyton rubrum and Trichophyton mentagrophytes augmented production of IL-8 and IL-1 α of cultured normal human epidermal keratinocytes. It was found that keratinocytes can recognize elements of dermatophytes as a pathogen.<br> Next we examined the effect of liranaftate, a representative Japanese thiocarbamate antifungal agent, on the production of IL-8 and IL-1 α. Keratinocytes were incubated with this antifungal drug in the presence of β -glucan or trichophytin. Augmented production of IL-8 was profoundly suppressed by the addition of liranaftate to the culture in a dose-dependent manner. Clinically, liranaftate an antifungal drug with IL-8-decreasing activity may reduce infiltration of neutrophils in the skin and their invasion into the epidermis.

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