有機塩素系化合物投与によるマウス肝臓DNAの損傷について
書誌事項
- タイトル別名
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- Hepatic DNA Damage in Mice Given Organochlorine Chemicals
抄録
The effects of organochlorine chemicals, mainly pesticides, on DNA single-strand breaks (DNA SSB) and the formation of 8-hydroxydeoxyguanosine (8-OHdG) in DNA were examined in mouse liver. Male mice were treated with organochlorine chemicals per os for 5 days, and killed 4hrs after the last administration. The daily dose of each chemical was about one-fifth of the reported LD50. The chemicals examined were endrin, dieldrin, γ-BHC, chlorpyrifos, heptachlor, pentachloronitrobenzene, pp′-DDT, pentachlorophenol, chlordane, 2, 4-D, mirex, pentachlorobenzene, hexachlorobenzene, chlorobenzilate, methoxychlor and trichloroethylene. The administrations of dieldrin, heptachlor, chlordane, mirex, pentachlorobenzene, hexachlorobenzene, chlorobenzilate, and trichloroethylene significantly increased relative liver weight. The 8-OHdG level in hepatic DNA of vehicle-treated mice was 1.2per 105 dG and comparable values were found in all groups treated with the chemicals. Hepatic DNA SSBs in mice treated with trichloroethylene and pentachlorophenol were significantly enhanced, but the effect was slight.
収録刊行物
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- 食品衛生学雑誌
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食品衛生学雑誌 34 (1), 68-73_1, 1993
公益社団法人 日本食品衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390282679203682944
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- NII論文ID
- 130003693170
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- ISSN
- 18821006
- 00156426
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用不可