Immunohistochemical investigation of the coma blister and its pathogenesis

DOI 機関リポジトリ Web Site PubMed 参考文献25件 オープンアクセス
  • Kashiwagi Masayuki
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
  • Ishigami Akiko
    Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School
  • Hara Kenji
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
  • Matsusue Aya
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
  • Waters Brian
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
  • Takayama Mio
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University
  • Tokunaga Itsuo
    Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School
  • Nishimura Akiyoshi
    Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School
  • Kubo Shin-ichi
    Department of Forensic Medicine, Faculty of Medicine, Fukuoka University

書誌事項

公開日
2013
資源種別
journal article
DOI
  • 10.2152/jmi.60.256
公開者
国立大学法人　徳島大学医学部

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説明

The erythematous patches and vesicles that are observed in coma patients, usually from an overdose of medication, are known as coma blisters. However, it is unknown whether the degenerated sweat gland is a necrosis or apoptosis. We immunohistochemically examined such skin lesions to investigate the characteristics and pathogenesis of the coma blister. Skin lesions were obtained from a forensic autopsy case, a woman in her thirties, of caffeine intoxication. Those lesions were observed in the left femoral, the lower left thigh, and the right knee. Histologically, the skin lesions showed that the keratinocytes had necrosed and the epidermis was thin in some areas. Eccrine sweat gland degeneration was observed. Obvious inflammatory cell infiltrations were not detected. Immunohistochemically, we stained each skin lesion against CD3, CD8, CD45RO, cytokeratin, 70 kD heat shock protein, ubiquitin, 150 kD oxygen regulated protein, and caspase-cleaved keratin 18 neo-epitope M30. They were also stained with an in situ apoptosis detection kit. Degenerated sweat glands featured CD45RO and M30 immunoreactivity. Immunohistochemical staining for CD45RO, CK-L, and M30 might be useful to observe sweat gland degeneration in the coma blister. Therefore, the apoptosis might be related to coma blisters and sweat gland degenerations. J. Med. Invest. 60: 256-261, August, 2013

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