First Functionalized MRI Contrast Agent Recognizing Vascular Lesions

YAMAMOTO Tatsuhiro, IKUTA Kenjiro, OI Keiji, ABE Kohtaro, UWATOKU Toyokazu, MURATA Masaharu, SHIGETANI Noboru, YOSHIMITSU Kengo, SHIMOKAWA Hiroaki, KATAYAMA Yoshiki

doi:10.2116/analsci.20.5

First Functionalized MRI Contrast Agent Recognizing Vascular Lesions

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YAMAMOTO Tatsuhiro

Department of Applied Chemistry, Faculty of Engineering, Kyushu University
IKUTA Kenjiro

Department of Applied Chemistry, Faculty of Engineering, Kyushu University
OI Keiji

Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
ABE Kohtaro

Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
UWATOKU Toyokazu

Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
MURATA Masaharu

Department of Applied Chemistry, Faculty of Engineering, Kyushu University
SHIGETANI Noboru

Department of Radiology, Kyushu University Hospital
YOSHIMITSU Kengo

Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
SHIMOKAWA Hiroaki

Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
KATAYAMA Yoshiki

Department of Applied Chemistry, Faculty of Engineering, Kyushu University

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抄録

A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MRI. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water’s protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.