Development of Sensitive Analytical Approach for the Quantification of α-Lipoic Acid Using Boron Doped Diamond Electrode

STANKOVIC Dalibor M., MEHMETI Eda, KALCHER Kurt

doi:10.2116/analsci.32.847

Development of Sensitive Analytical Approach for the Quantification of α-Lipoic Acid Using Boron Doped Diamond Electrode

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STANKOVIC Dalibor M.

Innovation Center of the Faculty of Chemistry, University of Belgrade
MEHMETI Eda

Institute of Chemistry—Analytical Chemistry, Karl-Franzens University Graz
KALCHER Kurt

Institute of Chemistry—Analytical Chemistry, Karl-Franzens University Graz

書誌事項

公開日: 2016

資源種別: journal article

DOI

10.2116/analsci.32.847

公開者: 社団法人日本分析化学会

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説明

A boron doped diamond (BDD) electrode was investigated for use as an electrochemical sensor for α-lipoic acid (LA) using amperometric and differential pulse voltammetric detection. LA displays a well expressed oxidation peak at +0.9 V vs. Ag/AgCl in solutions with a pH value of 3. It was found that signals obtained are linearly related to the concentration range from 0.3 to 105 μM with detection limit of 0.088 μM. Interferences by common compounds such as ascorbic acid, uric acid and dopamine were tested and the method was successfully applied to the determination of LA in human body fluids where it gave recoveries in the range from 95 to 97%.