ウサギ膝関節内へのパパイン注入による実験的変形性関節症に対する高分子量ヒアルロン酸ナトリウム（ＳＬ‐１０１０）の効果

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書誌事項

タイトル別名
  • Effect of SL-1010 (sodium hyaluronate with high molecular weight) on experimental osteoarthritis induced by intra-articularly applied papain in rabbits.
  • ウサギ シツカンセツナイ エ ノ パパイン チュウニュウ ニ ヨル ジッケンテ
公開日
1992
資源種別
journal article
DOI
  • 10.1254/fpj.100.67
公開者
公益社団法人 日本薬理学会

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説明

Sodium hyaluronate (HA) with a molecular weight of approximately 600, 000 ?? 1, 200, 000 is, reportedly effective against osteoarthritis (OA). However, since HA with higher molecular weight is expected to be more effective against OA, we investigated the effects of HA (SL-1010) newly produced by fermentation with a molecular weight of 1, 800, 000 ?? 2, 100, 000 on the experimental OA induced by intraarticular injection of papain, into the knee joint of the rabbit, in comparison with those of HA with a molecular weight of about 950, 000 (HA-95). When 0.4, 0.8, and 1.6% papain (0.5ml) was injected into the knee joint of the animal twice with a 3-day interval, there were dose-dependent degenerative changes and a decrease in sulfated glycosaminoglycan (S-GAG) in the articular cartilage with slight synovial inflammatory changes 6 weeks after the final injection of papain. In this OA model, intraarticular application of SL-1010 slightly reduced the degeneration of articular cartilage, compared with the injections of HA-95 or saline (control). SL-1010 also caused a significant recovery in the S-GAG level which was decreased in the cartilage of the OA model, compared with the control. In addition, SL-1010 inhibited the release of 35S-GAG from the cartilage obtained from normal and OA model joints. These results suggest that SL-1010 is effective in inhibiting the degeneration of cartilage in the OA model, probably due to the recovery of the S-GAG level by reducing the release of S-GAG from the cartilage.

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