トリニトロベンゼンスルフォン酸および酢酸誘発ラット大腸炎モデルにおけるプラウノトールの効果

書誌事項

タイトル別名
  • Effect of plaunotol on trinitrobenzene sulfonic acid and acetic acid induced colonic lesions in rats.
  • トリニトロベンゼンスルフォンサン オヨビ サクサン ユウハツ ラット ダイチョ

この論文をさがす

抄録

The aim of this study was to assess the effect of plaunotol, an anti-ulcer agent, on trinitrobenzene sulfonic acid (TNB)- and acetic acid-induced colonic lesions in rats. Plaunotol significantly reduced the severity of colonic mucosal lesions induced by TNB at a dose of 600 mg/kg/day. Moreover, plaunotol, at a dose of 600 mg/kg/day, significantly depressed the myeloperoxidase activity of the lesioned area induced by TNB of the rat colon. In the model of colitis induced by acetic acid, plaunotol reduced the area of lesions dosedependently and significantly at doses of 60, 200 and 600 mg/kg/day as asessed by macroscopic observation. Microscopic observation showed obvious changes by administration of plaunotol such as reduction of epithelial cell necrosis, decreased mucin production and a decreased infiltration of a large number of neutrophils. In conclusion, plaunotol showed a protective effect against colonic lesion formation induced by TNB and acetic acid in rats. This study suggests the possibility that plaunotol may be effective and useful for treatment of inflammatory bowel disease in humans.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 112 (2), 97-106, 1998

    公益社団法人 日本薬理学会

被引用文献 (2)*注記

もっと見る

参考文献 (28)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ