書誌事項
- タイトル別名
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- Effect of plaunotol on trinitrobenzene sulfonic acid and acetic acid induced colonic lesions in rats.
- トリニトロベンゼンスルフォンサン オヨビ サクサン ユウハツ ラット ダイチョ
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The aim of this study was to assess the effect of plaunotol, an anti-ulcer agent, on trinitrobenzene sulfonic acid (TNB)- and acetic acid-induced colonic lesions in rats. Plaunotol significantly reduced the severity of colonic mucosal lesions induced by TNB at a dose of 600 mg/kg/day. Moreover, plaunotol, at a dose of 600 mg/kg/day, significantly depressed the myeloperoxidase activity of the lesioned area induced by TNB of the rat colon. In the model of colitis induced by acetic acid, plaunotol reduced the area of lesions dosedependently and significantly at doses of 60, 200 and 600 mg/kg/day as asessed by macroscopic observation. Microscopic observation showed obvious changes by administration of plaunotol such as reduction of epithelial cell necrosis, decreased mucin production and a decreased infiltration of a large number of neutrophils. In conclusion, plaunotol showed a protective effect against colonic lesion formation induced by TNB and acetic acid in rats. This study suggests the possibility that plaunotol may be effective and useful for treatment of inflammatory bowel disease in humans.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 112 (2), 97-106, 1998
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679249988736
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- NII論文ID
- 10005086260
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaK1cXltVarsLs%3D
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- ISSN
- 13478397
- 00155691
- http://id.crossref.org/issn/00155691
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- NDL書誌ID
- 4527217
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- PubMed
- 9785600
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可