Contribution of NMDA Receptors to Activity of Augmenting Epiratory Neurons in Vagotomized Cats
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- Haji Akira
- Department of Pharmacology,Faculty of Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
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- Okazaki Mari
- Department of Pharmacology,Faculty of Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
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- Takeda Ryuji
- Department of Pharmacology,Faculty of Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
書誌事項
- タイトル別名
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- Contribution of NMDA Receptors to Activity of Augmenting Expiratory Neurons in Vagotomized Cats.
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抄録
To identify the NMDA receptor-mediated mechanism in augmenting expiratory(E2)neurons, the effects of systemic and local application of dizocilpine on spontaneous and evoked postsynaptic potentials(PSPs)were investigated in decerebrate and vagotomized cats.Intravenously applied dizocilpine reduced the inhibitory PSPs during inspiration and stage 1 expiration, but had little effect on the excitatory PSPs during stage 2 expiration.Iontophoresed dizocilpine caused a continuous hyperpolarization throughout the respiratory cycle.Dizocilpine had no effect on vagally evoked PSPs.These results suggest that the NMDA mechanisms are involved presynaptically in periodic postsynaptic inhibitions and postsynaptically in tonic excitation in E2 neurons.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 82 (4), 353-357, 2000
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679264442496
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- NII論文ID
- 10008184056
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3cXisl2gsb4%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 5362840
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- PubMed
- 10875757
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I5362840
- https://api.elsevier.com/content/article/PII:S0021519819306742?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819306742?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/82/4/82_4_353/_pdf
- https://search.jamas.or.jp/link/ui/2000188131
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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