Effect of Zaldaride Maleate, an Antidiarrheal Compound, on Fecal Pellet Output Induced by Hyperpropulsion in Gastrointestine of Rats.
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- Aikawa Nobuo
- Drug Development Research Laboratories,Pharmaceutical Research Institute,Kyowa Hakko Kogyo Co.,Ltd.,1188 Shimotogari,Nagaizumi-cho,Sunto-gun,Shizuoka 411-8731,Japan
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- Ohmori Kenji
- Drug Development Research Laboratories,Pharmaceutical Research Institute,Kyowa Hakko Kogyo Co.,Ltd.,1188 Shimotogari,Nagaizumi-cho,Sunto-gun,Shizuoka 411-8731,Japan
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The effect of zaldaride, a calmodulin inhibitor, on fecal pellet output in rats was compared with that of loperamide, an antidiarrheal drug.5-Hydroxytryptamine(10mg/kg, s.c.), neostigmine(0.3mg/kg, s.c.)and nicotine(1.0mg/kg, s.c.)increased fecal pellet output.Zaldaride(≥30mg/kg, p.o.)reduced these increases in facal pellet outputs.Loperamide(10mg/kg, p.o.)inhibited fecal pellet output induced by 5-hydroxytryptamine and neostigmine but not nicotine.Under normal conditions, zaldaride and loperamide did not affect fecal pellet output at doses used in these studies.In conclusion, zaldaride may inhibit increases in fecal pellet output induced by hyperpropulsion of the gastrointestinal tract without causing constipation as a side effect.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 82 (4), 350-352, 2000
公益社団法人 日本薬理学会
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詳細情報
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- CRID
- 1390282679264443648
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- NII論文ID
- 10008184040
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3cXisl2gsLc%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 5362831
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- PubMed
- 10875756
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可