EXPERIMENTAL PULMONARY EDEMA IN RODENTS FOLLOWING A SINGLE INJECTION OF 4-NITROQUINOLINE 1-OXIDE

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Administration of 4-nitroquinoline 1-oxide has been known to produce pulmonary tumors in rodents (1-3). An electron microscopic examination on the lung of rats shortly after an injection of this compound revealed induction of nucleolar segregation in the alveolar epithelial cells (4). In this experiment, it was further shown that an injection of 4-nitroquinoline 1-oxide could produce pulmonary edema in rats as well as in guineapigs and rabbits.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 20 (2), 264-271, 1970

    公益社団法人 日本薬理学会

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