Studies of combination dosing-3-Aspirin and ethenzamide

KAWANO Osamu, SAWABE Takashi, MISAKI Noriyuki, FUKAWA Kazunaga

doi:10.1254/jjp.28.829

Studies of combination dosing-3-Aspirin and ethenzamide

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KAWANO Osamu

Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.
SAWABE Takashi

Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.
MISAKI Noriyuki

Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.
FUKAWA Kazunaga

Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.

書誌事項

タイトル別名

Studies on combination dosing. III. Aspirin and ethenzamide.
Studies of combination dosing 3 Aspirin

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抄録

In our studies with drug combinations, we searched for mixtures which would enhance the effectiveness of the related active substances. Ethenzamide was found to possess a specific suppressive effect on the gastric damage induced by aspirin. Such effect could not be demonstrated in analgesic agents such as salicylamide, bucetin, acetaminophen and phenacetin. The combination of aspirin with ethenzamide had a potentiating effect on analgesic activity and reduced motor incoordination and loss of righting reflex. We calculated the safety margins of various ratios of combinations and concluded that the best was aspirin and ethenzamide at a ratio of 2:3.